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Science 28 December 1973:
Vol. 182. no. 4119, pp. 1350 - 1352
DOI: 10.1126/science.182.4119.1350
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Articles

beta2-Microglobulin: Association with Lymphocyte Receptors

Marilyn L. Bach 1, Shi-Wen Huang 1, Richard Hong 1, and M. David Poulik 2

1 Departments of Pediatrics, Pharmacology, and Microbiology, University of Wisconsin, Madison 53706
2 Department of Immunochemistry. Wayne State School of Medicine, William Beaumont Hospital, Royal Oak, Michigan 48072

beta2-Microglobulin (beta2m) is a low-molecular-weight protein constituent of lymphocyte membranes. Amino acid sequence analysis has revealed a high degree of homology between the beta2m and certain regions of immunoglobulin molecules, suggesting a possible recognition function for the beta2m, in analogy with the immunoglobulins. The data presented demonstrate that highly specific antiserum against beta2m blocks lymphocyte reactivity against allogeneic cells in mixed leukcocyte cultures and against phytohemagglutinin, both of which processes presumably function via a cell surface receptor on thymus-derived (T) lymphocytes. There is very little inhibition of T lymphocyte rosette formation with sheep red blood cells. The findings suggest a possible relation between the beta2m and recognition units on the T lymphocyte surface.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Elevated salivary and synovial fluid beta2-microglobulin in Sjogren's syndrome and rheumatoid arthritis.
N Talal, H. Grey, N Zvaifler, J. Michalski, and T. Daniels (1975)
Science 187, 1196-1198
   Abstract »    PDF »
Aggregation of HL-A Antigens at the Lymphocyte Surface Induced by Antiserum to beta2-Microglobulin.
M. D. Poulik, M. Bernoco, D. Bernoco, and R. Ceppellinni (1973)
Science 182, 1352-1355
   Abstract »    PDF »


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