Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 21 December 1973:
Vol. 182. no. 4118, pp. 1253 - 1254
DOI: 10.1126/science.182.4118.1253
Prev | Table of Contents | Next

Articles

Membrane Fatty Acids Associated with the Electrical Response in Visual Excitation

R. M. Benolken 1, Robert E. Anderson 2, and Thomas G. Wheeler 3

1 University of Texas, Graduate School of Biomedical Sciences, Texas Medical Center, Houston 77025
2 Depatrment of Ophthalmology, Baylor College of Medicine, Texas Medical Center
3 University of Texas, Graduate School of Biomedical Sciences

The fatty acid composition of rat photoreceptor membranes was altered by dietary manipulation. A functional alteration was also observed in the component of the electroretinogram which is generated by the photoreceptors. A membrane fatty acid, docosahexaenoic acid, appears to be involved in the transduction process of visual excitation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
High levels of retinal membrane docosahexaenoic acid increase susceptibility to stress-induced degeneration.
M. Tanito, R. S. Brush, M. H. Elliott, L. D. Wicker, K. R. Henry, and R. E. Anderson (2009)
J. Lipid Res. 50, 807-819
   Abstract »    Full Text »    PDF »
Homeostatic Regulation of Photoreceptor Cell Integrity: Significance of the Potent Mediator Neuroprotectin D1 Biosynthesized from Docosahexaenoic Acid The Proctor Lecture.
N. G. Bazan (2007)
Invest. Ophthalmol. Vis. Sci. 48, 4866-4881
   Full Text »    PDF »
n-3 Fatty acid dietary recommendations and food sources to achieve essentiality and cardiovascular benefits.
S. K Gebauer, T. L Psota, W. S Harris, and P. M Kris-Etherton (2006)
Am. J. Clinical Nutrition 83, S1526-1535S
   Abstract »    Full Text »    PDF »
Is docosahexaenoic acid, an n-3 long-chain polyunsaturated fatty acid, required for development of normal brain function? An overview of evidence from cognitive and behavioral tests in humans and animals.
J. C McCann and B. N Ames (2005)
Am. J. Clinical Nutrition 82, 281-295
   Abstract »    Full Text »    PDF »
Long-Chain (n-3) Polyunsaturated Fatty Acids Are More Efficient than {alpha}-Linolenic Acid in Improving Electroretinogram Responses of Puppies Exposed during Gestation, Lactation, and Weaning.
K. M. Heinemann, M. K. Waldron, K. E. Bigley, G. E. Lees, and J. E. Bauer (2005)
J. Nutr. 135, 1960-1966
   Abstract »    Full Text »    PDF »
Directly Quantitated Dietary (n-3) Fatty Acid Intakes of Pregnant Canadian Women Are Lower than Current Dietary Recommendations.
J. Denomme, K. D. Stark, and B. J. Holub (2005)
J. Nutr. 135, 206-211
   Abstract »    Full Text »    PDF »
Docosahexaenoic and Arachidonic Acid Influence on Preterm Baboon Retinal Composition and Function.
G.-Y. Diau, E. R. Loew, V. Wijendran, E. Sarkadi-Nagy, P. W. Nathanielsz, and J. T. Brenna (2003)
Invest. Ophthalmol. Vis. Sci. 44, 4559-4566
   Abstract »    Full Text »    PDF »
Scotopic Electroretinogram in Term Infants Born of Mothers Supplemented with Docosahexaenoic Acid during Pregnancy.
C. A. Malcolm, R. Hamilton, D. L. McCulloch, C. Montgomery, and L. T. Weaver (2003)
Invest. Ophthalmol. Vis. Sci. 44, 3685-3691
   Abstract »    Full Text »    PDF »
n-3 Fatty Acid Deficiency Alters Recovery of the Rod Photoresponse in Rhesus Monkeys.
B. G. Jeffrey, D. C. Mitchell, R. A. Gibson, and M. Neuringer (2002)
Invest. Ophthalmol. Vis. Sci. 43, 2806-2814
   Abstract »    Full Text »    PDF »
Impaired synthesis of DHA in patients with X-linked retinitis pigmentosa.
D. R. Hoffman, J. C. DeMar, W. C. Heird, D. G. Birch, and R. E. Anderson (2001)
J. Lipid Res. 42, 1395-1401
   Abstract »    Full Text »    PDF »
Low Docosahexaenoic Acid Levels in Rod Outer Segment Membranes of Mice with rds/Peripherin and P216L Peripherin Mutations.
R. E. Anderson, M. B. Maude, and D. Bok (2001)
Invest. Ophthalmol. Vis. Sci. 42, 1715-1720
   Abstract »    Full Text »    PDF »
Changes in Maze Behavior of Mice Occur after Sufficient Accumulation of Docosahexaenoic Acid in Brain.
S.-Y. Lim and H. Suzuki (2001)
J. Nutr. 131, 319-324
   Abstract »    Full Text »
Protective Effects of Dietary Docosahexaenoic Acid against Kainate-Induced Retinal Degeneration in Rats.
A. Mizota, E. Sato, M. Taniai, E. Adachi–Usami, and M. Nishikawa (2001)
Invest. Ophthalmol. Vis. Sci. 42, 216-221
   Abstract »    Full Text »
Essential fatty acids in infant nutrition: lessons and limitations from animal studies in relation to studies on infant fatty acid requirements.
S. M Innis (2000)
Am. J. Clinical Nutrition 71, 238S-244S
   Abstract »    Full Text »    PDF »
Infant vision and retinal function in studies of dietary long-chain polyunsaturated fatty acids: methods, results, and implications1,2,3.
M. Neuringer (2000)
Am. J. Clinical Nutrition 71, 256S-267S
   Abstract »    Full Text »    PDF »
High-Linoleate and High-{alpha}-Linolenate Diets Affect Learning Ability and Natural Behavior in SAMR1 Mice.
M. Umezawa, K. Kogishi, H. Tojo, S. Yoshimura, N. Seriu, A. Ohta, T. Takeda, and M. Hosokawa (1999)
J. Nutr. 129, 431-437
   Abstract »    Full Text »    PDF »
Visual membranes: specificity of fatty acid precursors for the electrical response to illumination.
T. Wheeler, R. Benolken, and R. Anderson (1975)
Science 188, 1312-1314
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)