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Science 14 December 1973:
Vol. 182. no. 4117, pp. 1136 - 1138
DOI: 10.1126/science.182.4117.1136
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Articles

Direct Evidence for a Colchicine-Induced Impairment in the Mobility of Membrane Components

F. Wunderlich 1, R. Müller 1, and V. Speth 2

1 Department of Biology II, University of Freiburg, Freiburg i. Br. Germany-W.
2 Max-Planck-Institut für Immunbiologie, Freiburg i. Br. Germany-W.

Freeze-etch electron microscopy was used to show that colchicine interacts with membranes of the ciliate protozoan Tetrahymena pyriformis. Colchicine impairs the temperature-induced translational and vertical mobility of the membrane-intercalating particles of the freeze-fractured alveolar membranes lying just below the plasma membranes.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Control of ACh Sensitivity in Rat Muscle Fibers.
T. Lomo and R. H. Westgaard (1976)
Cold Spring Harb Symp Quant Biol 40, 263-274
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Science. ISSN 0036-8075 (print), 1095-9203 (online)