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Science 14 December 1973:
Vol. 182. no. 4117, pp. 1135 - 1136
DOI: 10.1126/science.182.4117.1135
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Articles

Bicyclic Phosphorus Esters: High Toxicity without Cholinesterase Inhibition

Eugene M. Bellet 1 and John E. Casida 1

1 Division of Entomology and Parasitology, University of California, Berkeley 94720

4-Isopropyl-2,6,7-trioxa-1-phosphabicyclo[2.2.2]octane 1-oxide has a mouse intraperitoneal lethal dose, 50 percent effective, of 0.18 milligram per kilogram of body weight. Related compounds used by many chemical researchers are also highly toxic. Brain acetylcholinesterase inhibition is not involved in their mode of action. The structural similarity of these compounds to adenosine 3',5'-monophosphate (cyclic AMP) is of interest.


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