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Science 7 December 1973:
Vol. 182. no. 4116, pp. 1026 - 1028
DOI: 10.1126/science.182.4116.1026
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Articles

Hepatitis A: Detection by Immune Electron Microscopy of a Viruslike Antigen Associated with Acute Illness

Stephen M. Feinstone 1, Albert Z. Kapikian 1, and Robert H. Purcell 1

1 Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014

Spherical 27-nanometer particles were visualized in stools obtained from hepatitis A patients in the acute phase of the disease. The particle was serologically specific for this disease, and every hepatitis A patient tested demonstrated a serologic response to this antigen. The findings suggest that it is the etiologic agent of hepatitis A.


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