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Science 30 November 1973:
Vol. 182. no. 4115, pp. 923 - 924
DOI: 10.1126/science.182.4115.923
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Articles

Dopamine-beta-Hydroxylase: Evidence for Increased Activity in Sympathetic Neurons during Psychotic States

Seymour Rosenblatt 1, W. P. Leighton 1, and J. D. Chanley 2

1 Department of Psychiatry, Mount Sinai School of Medicine of the City University of New York, Fifth Avenue and 100th Street, New York 10029
2 Department of Biochemistry, Mount Sinai School of Medicine of the City University of New York

Tritiated dopamine was infused into psychiatric patients during acute psychotic episodes and in remission. An index of the activity of dopamine-beta-hydroxylase of salivary gland sympathetic neurons was determined by measuring the distribution of tritiated metabolites in salivary fluid. Increased synthesis of norepinephrine occurred in acute schizophrenia and in the manic state of manic-depressive psychosis but not in the depressed phase.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)