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Science 23 November 1973:
Vol. 182. no. 4114, pp. 841 - 842
DOI: 10.1126/science.182.4114.841
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Articles

Porphyrin-Heme Pathway: Regulation by Intermediates in Bile Acid Synthesis

Norman B. Javitt 1, Arleen Rifkind 1, and Attallah Kappas 1

1 Department of Medicine, Cornell Medical College, and Rockefeller University Hospital, New York 10021

Dihydroxycoprostane and trihydroxycoprostane, intermediates in normal bile acid synthesis in the liver, enhanced the rate of porphyrin synthesis in cultured liver cells by induction of dgr-aminolevulinate synthetase, the rate-limiting enzyme for this pathway. Other 5beta-cholestane derivatives and cholest-5-ene derivatives were ineffective. The selectivity of the induction may indicate that the above-mentioned coprostanes have a physiological role in porphyrin synthesis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Acute Intermittent Porphyria: Clinical and Selected Research Aspects.
D. P. TSCHUDY, M. VALSAMIS, and C. R. MAGNUSSEN (1975)
Ann Intern Med 83, 851-864
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