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Science 23 November 1973:
Vol. 182. no. 4114, pp. 829 - 831
DOI: 10.1126/science.182.4114.829
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Articles

"Big" Growth Hormone Components from Human Plasma: Decreased Reactivity Demonstrated by Radioreceptor Assay

P. Gorden 1, M. A. Lesniak 1, C. M. Hendricks 1, and J. Roth 1

1 National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014

Plasma as well as pituitary immunoreactive human growth hormone (HGH) comprises at least two discrete components which have been designated as "big" HGH and "little" HGH. Using a newly developed radioreceptor assay, which depends on the ability of a substance to compete with labeled HGH for binding sites on cultured human lymphocytes, we find that the big HGH component from both normal and acromegalic subjects has much less activity in the radioreceptor assay than in the radioimmunoassay, whereas the little HGH component has simnilar activity in both assays.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Growth hormone: independent release of big and small forms from rat pituitary in vitro.
M. Stachura and L. Frohman (1975)
Science 187, 447-449
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