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Science 16 November 1973:
Vol. 182. no. 4113, pp. 722 - 723
DOI: 10.1126/science.182.4113.722
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Articles

Retinyl Acetate: Effect on Cellular Content of RNA in Epidermis in Cell Culture in Chemically Defined Medium

Michael B. Sporn 1, Nancy M. Dunlop 1, and Stuart H. Yuspa 2

1 Lung Cancer Branch
2 Experimenetital Pathology Branch, Carcinogenesis Program, National Cancer Instituite, Bethesda, Maryland 20014

Cell cultures of epidermis from newborn mice were established in chemically defined medium. Additions of retinyl acetate to these cultures caused a significant increase in cellular RNA content. Addition of insulin and hydrocortisone to the cultures potentiated the effect of retinyl acetate on cellular RNA content.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)