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Science 16 November 1973:
Vol. 182. no. 4113, pp. 713 - 715
DOI: 10.1126/science.182.4113.713
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Articles

Antibodies to Herpesvirus Nonvirion Antigens in Squamous Carcinomas

Ariel C. Hollinshead 1, Obong Lee 1, Paul B. Chretien 2, John L. Tarpley 2, William E. Rawls 3, and Ervin Adam 3

1 Laboratory for Virus and Cancer Research, Department of Medicine, George Washington University, Washington, D.C. 20037
2 Surgery Branch, National Cancer Institute, Bethesda, Maryland 20014
3 Departments of Virology and Epidemiology, Baylor University College of Medicine, Texas Medical Center, Houston 77025

Serums from tumor-bearing patients, cured patients, and normal subjects were examined for antibodies to the separated complement-fixing reactive components of nonvirion antigens of herpesvirus type 1 and type 2. The occurrence of antibodies to the antigens was similar in serums from tumor-bearing patients and cured patients. Antibodies to the antigens were observed among 21 of 24 (87 percent) cervical cancer cases, 44 of 49 (90 percent) laryngeal cancer cases, 15 of 24 (62 percent) cases of squamous cell carcinomas of the head and neck excluding the larynx, 2 of 24 (8 percent) nonsquamous cell cancer cases, and 3 of 51 (6 percent) normal subjects. By contrast, no differences were found in the titers of neutralizing antibodies to the virus in serums from laryngeal cancer patients and controls. The observations support an etiologic role of herpesviruses in cervical cancer and in laryngeal cancer, and possibly other squamous cell cancers of the head and neck.


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