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Science 9 November 1973:
Vol. 182. no. 4112, pp. 592 - 594
DOI: 10.1126/science.182.4112.592
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Articles

Rapid Viral Induction of Plasmacytomas in Pristane-Primed BALB/c Mice

Michael Potter 1, Marshall D. Sklar 2, and Wallace P. Rowe 2

1 Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014
2 Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases. National Institutes of Health

Strain BALB/c mice were injected intraperitoneally with 0.5 milliliter of pristane, and 39 to 56 days later they were infected with Abelson murine leukemia virus, which is a lymphosarcomagenic variant of Moloney virus. Fifty-eight percent of the mice developed lymphosarcoma, and 28 percent developed immunoglobulin-producing plasmacytomas within 20 to 93 days (77 to 149 days after the pristane injection). Two of 57 control mice developed plasmacytomas at days 138 and 166 after a single injection of pristane; no plasmacytomas were found in mice treated with virus alone.


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