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Science 19 October 1973:
Vol. 182. no. 4109, pp. 296 - 297
DOI: 10.1126/science.182.4109.296
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Articles

Proteins from Human Cerebrospinal Fluid: Binding with Nucleic Acids

H. Kubinski 1 and Manucher Javid 1

1 Division of Neurological Surgery, University Hospitals, Madison, Wisconsin 53706

Cerebrospinal fluid (CSF) contains two groups of proteins that bind tightly to DNA and to polyriboguanylic acid, respectively. In certain diseases the amounts of a given nucleic acid bound by a constant volume of CSF may increase, while in others the amount of such proteins may be reduced. Binding of polyriboguanylic acid increased in CSF samples from patients with brain tumors, stroke, multiple sclerosis, and communicating hydrocephalus, but it significantly decreased in CSF samples from patients with obstructive hydrocephalus. These increases may or may not be proportional to the rise in total CSF proteins characteristic for these diseases. Elevated binding of DNA was observed in samples from patients with hydrocephalus, epilepsy, and cortical atrophy. The technique described may be applicable to the diagnosis of a variety of diseases of the central nervous system.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)