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Science 19 October 1973:
Vol. 182. no. 4109, pp. 287 - 291
DOI: 10.1126/science.182.4109.287
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Articles

Complete Amino Acid Sequence of the Mu Heavy Chain of a Human IgM Immunoglobulin

F. W. Putnam 1, G. Florent 1, C. Paul 1, T. Shinoda 1, and A. Shimizu 1

1 Department of Zoology, Indiana University, Bloomington 47401

The amino acid sequence of the µ, chain of a human IgM immunoglobulin, including the location of all disulfide bridges and oligosaccharides, has been determined. The homology of the constant regions of immunoglobulin µ, ggr, agr, and egr heavy chains reveals evolutionary relationships and suggests that two genes code for each heavy chain.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Mutations in the Mu Heavy-Chain Gene in Patients with Agammaglobulinemia.
L. Yel, Y. Minegishi, E. Coustan-Smith, R. H. Buckley, H. Trubel, L. M. Pachman, G. R. Kitchingman, D. Campana, J. Rohrer, and M. E. Conley (1996)
N. Engl. J. Med. 335, 1486-1493
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Neuronal cell Thy-1 glycoprotein: homology with immunoglobulin.
A. Williams and J Gagnon (1982)
Science 216, 696-703
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Amino acid sequence of the Fc region of a canine immunoglobulin M: interspecies homology for the IgM class.
R. Wasserman and J. Capra (1978)
Science 200, 1159-1161
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Complete covalent structure of a human IgA1 immunoglobulin.
Y. Liu, T. Low, A Infante, and F. Putnam (1976)
Science 193, 1017-1020
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Structure, function, and evolutionary relationships of Fc domains of human immunoglobulins A, G, M, and E.
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Science 191, 390-392
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Control of Bisecting GlcNAc Addition to N-Linked Sugar Chains.
K. Fukuta, R. Abe, T. Yokomatsu, F. Omae, M. Asanagi, and T. Makino (2000)
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