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Science 19 October 1973:
Vol. 182. no. 4109, pp. 283 - 285
DOI: 10.1126/science.182.4109.283
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Articles

Copulation in Castrated Male Rats following Combined Treatment with Estradiol and Dihydrotestosterone

Michael J. Baum 1 and J. T. M. Vreeburg 1

1 Department of Endocrinology, Growth and Reproduction, Erasmus University, Rotterdam, Netherlands

Castrated male rats injected daily with 2 micrograms of estradiol benzoate (EB) combined with 200 micrograms of dihydrotestosterone propionate (DHTP) displayed masculine mating behavior which was indistinguishable from that of other castrates treated with 200 micrograms of testosterone propionate (TP). Significantly less copulation was seen in rats treated with either 4 micrograms of TP plus 200 micrograms of DHTP or 2 micrograms of EB. Mating in male rats may depend on the action of both estrogenic and 5agr-dihydro metabolites of testosterone.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)