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Science 12 October 1973:
Vol. 182. no. 4108, pp. 175 - 177
DOI: 10.1126/science.182.4108.175
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Articles

Instrumental Conditioning of Large-Magnitude, Daily, 12-Hour Blood Pressure Elevations in the Baboon

Alan H. Harris 1, Willie J. Gilliam 1, Jack D. Findley 1, and Joseph V. Brady 1

1 Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

Blood pressure and heart rate were monitored continuously in four baboons during extended exposure to a daily 12-hour conditioning procedure providing food and shock-avoidance as contingent consequences of prespecified increases in diastolic blood pressure. Sustained and significant increases (30 to 40 mm-Hg) in both systolic and diastolic blood pressure were maintained throughout the daily 12-hour conditioning sessions, accompanied by elevated heart rates.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Baroreceptor activation reduces reactivity to noxious stimulation: implications for hypertension.
B. Dworkin, R. Filewich, N. Miller, N Craigmyle, and T. Pickering (1979)
Science 205, 1299-1301
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