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Science 5 October 1973:
Vol. 182. no. 4107, pp. 78 - 79
DOI: 10.1126/science.182.4107.78
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Articles

Vitamin B12 and the Megaloblastic Development

Farid I. Haurani 1

1 Cardeza Foundation for Hematologic Research, Thomas Jefferson University, Phliladelphia, Pennsylvania 19107

In patients with vitamin B12 deficiency, phytohemagglutinin-stimulated cultured lymphocytes had little or no thymidylate synthetase activity. Ample activity was found in such lymphocytes from normal individuals and patients with folic acid deficiency or pernicious anemia in remission. It therefore appears that the megaloblastosis that is associated with vitamin B12 deficiency is related to low thymidylate synthetase activity.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)