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Science 5 October 1973:
Vol. 182. no. 4107, pp. 76 - 78
DOI: 10.1126/science.182.4107.76
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Articles

Prevention of Murine Lupus Nephritis by Carrier-Dependent Induction of Immunologic Tolerance to Denatured DNA

Yves Borel 1, Robert M. Lewis 1, and B. David Stollar 1

1 Departments of Medicine, Surgery, and Biochemistry, New England Medical Center Hospital, Tufts University School of Medicine, Boston, Massachusetts 02111

Four nucleosides were covalently bound to isogeneic mouse immunoglobulin G (IgG) and injected into New Zealand mice. Mice that received the tetranucleoside isogeneic IgG from birth to 5 months of age failed to make antibody to denatured DNA. In contrast, mice that were similarly treated with tetranucleoside bovine serum albumin or tetranucleoside free of carrier produced the same amount of antibody to denatured DNA as did untreated mice of this strain. Mice that were rendered tolerant to denatured DNA by tetranucleoside isogeneic IgG failed to develop the chronic membranous glomerulonephritis that characterizes the renal lesions in animals of this strain.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Conjugates or dsDNA Linked to Human Gammaglobulin Inhibit Anti-dsDNA Antibodies In Vitro.
N. Mikael, M. Boguniewicz, Y. Manakata, T. Sasaki, H. Borel, and Y. Borel (1994)
Lupus 3, 173-179
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