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Science 5 October 1973:
Vol. 182. no. 4107, pp. 60 - 61
DOI: 10.1126/science.182.4107.60
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Articles

Dopa and Dopamine in Glusulase: Possible Artifact in Studies on Catecholamine Metabolism

A. H. Anton 1, A. Serrano 1, T. B. Tjandramaga 2, and L. I. Goldberg 2

1 Departments of Anesthesiology and Pharmacology, Case Western Reserve School of Medicine, Cleveland, Ohio 44106
2 Clinical Pharmacology Program, Departments of Medicine and Pharmacology, Emory School of Medicine, Atlanta, Georgia 30322

Relatively high concentrations of dopa and dopamnine were found in Glusulase, an enzyme preparation widely used in studies on catecholamine metabolism. This contamination may be a source of error in some studies, particularly in those measuring the endogenous concentrations of these catechols and their metabolic products.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)