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Science 28 September 1973:
Vol. 181. no. 4106, pp. 1249 - 1252
DOI: 10.1126/science.181.4106.1249
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Articles

Recombinant Inbred Lines: Value in the Genetic Analysis of Biochemical Variants

Richard T. Swank 1 and D. W. Bailey 2

1 Department of Molecular Biology, Roswell Park Memorial Institute, Buffalo, New York 14203
2 Jackson Laboratory, Bar Harbor, Maine 04609

Analysis of inducibility by androgens and electrophoretic mobility of kidney glucuronidase in progenitor and derived recombinant inbred mouse lines suggests that a single major regulatory gene at or near the glucuronidase structural gene on chromosome 5 determines the rate of enzyme accumulation.


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