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Science 21 September 1973:
Vol. 181. no. 4105, pp. 1172 - 1175
DOI: 10.1126/science.181.4105.1172
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Articles

Subfornical Organ: Site of Drinking Elicitation by Angiotensin II

John B. Simpson 1 and Aryeh Routtenberg 1

1 Departments of Psychology and Biological Sciences, Cresap Laboratory of Neuroscience and Behavior, Northwestern University, Evanston, Illinois 60201

Angiotensin II applied directly to the subfornical organ in a dose as small as 0.1 nanogram elicited short-latency drinking behavior in water-sated rats. Lesions in the body of this structure blocked drinking induced by angiotensin II applied to the basal telencephalon (including preoptic area). These results call attention to the subfornical organ as an important central nervous structure involved in the conrol of drinking behavior.


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