Catecholamine and Dibutyryl Cyclic AMP Effects on Myosin Adenosine Triphosphatase in Cultured Rat Heart Cells
Isaac Harary 1,
Frank Hoover 2, and
Barbara Farley 2
1 Laboratory of Nuclear Medicine and Radiation Biology and Molecular Biology Institute, University of California, Los Angeles 90024, and Department of Biological Chemistry, University of California School of Medicine, Los Angeles 90024
2 Laboratory of Nuclear Medicine and Radiation Biology, University of California, Los Angeles
Catecholamines and dibutyryl adenosine 3', 5'-monophosphate (dibutyryl cyclic AMP) increase the activity of myosin adenosine triphosphatase in cultured rat heart cells. Dichloroisoproterenol, an inhibitor of the beta receptor of the catecholamines, inhibits the action of the catecholamines but not of cyclic AMP.