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Science 7 September 1973:
Vol. 181. no. 4103, pp. 957 - 959
DOI: 10.1126/science.181.4103.957
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Articles

Immunity to Colon Cancer Assessed by Antigen-Induced Inhibition of Mixed Mononuclear Cell Migration

David M. Bull 1, Jon R. Leibach 2, Marjorie A. Williams 2, and Richard A. Helms 3

1 Department of Medicine, Ohio State University College of Medicine, Columbus 43210, and Thorndike Memorial Laboratory, Harvard Medical Unit, Boston City Hospital, Boston, Massachusetts 02118
2 Department of Medicine, Ohio State University College of Medicine
3 Thorndike Memorial Laboratory, Harvard Medical Unit, Boston City Hospital

A purified preparation of mixed human peripheral blood lymphocytes and monocytes was used in an inhibition-of-migration assay for cell-mediated immunity to cancer of the colon. This preparation was reproducibly antigen-responsive and migrated with greater reliability than did a more complex cell mixture. Of 27 patients with this disease, cells from 24 showed inhibited migratio in response to colon carcinoma antigen. Uninhibited migration patterns were found in each of the 52 cancer-free controls, including eight patients with nonmalignant disease initially diagnosed as cancer of the colon, and in nine patients with surgically cured adenocarcinoma of the colon.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Lymphokine Production and Lymphocyte Subpopulations in Patients With Head and Neck Squamous Carcinoma.
G. T. Wolf, E. J. Lovett III, K. A. Peterson, M. L. Beauchamp, and S. R. Baker (1984)
Arch Otolaryngol Head Neck Surg 110, 731-735
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Science. ISSN 0036-8075 (print), 1095-9203 (online)