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Science 7 September 1973:
Vol. 181. no. 4103, pp. 954 - 955
DOI: 10.1126/science.181.4103.954
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Articles

Zinc: A Trace Element Essential in Vitamin A Metabolism

J. Cecil Smith Jr. 1, E. G. McDaniel 1, F. F. Fan 1, and James A. Halsted 1

1 Veterans Administration Hospital, Washington, D.C. 20422, and National Institutes of Health, Bethesda, Maryland 20014, and School of Medicine, George Washington University, Washington, D.C. 20005

Zinc is necessary to maintain normal concentrations of vitamin A in plasma. By using animals deficient in both zinc and vitamin A, it was demonstrated that zinc is necessary for normal mobilization of vitamin A from the liver. These results suggest that cases of depressed vitamin A in plasma, unresponsive to vitamin A therapy, may respond to zinc supplementation.


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