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Science 7 September 1973:
Vol. 181. no. 4103, pp. 952 - 954
DOI: 10.1126/science.181.4103.952
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Articles

Regulation of Phosphodiesterase Synthesis: Requirement for Cyclic Adenosine Monophosphate-Dependent Protein Kinase

Henry R. Bourne 1, G. M. Tomkins 1, and Sally Dion 1

1 Departments of Medicine, Pharmacology, and Biochemistry, University of California, San Francisco 94122

Endogenous cyclic adenosine monophosphate (AMP) and its dibutyryl derivative increase cyclic AMP phosphodiesterase activity in cultured lymphoma cells. This effect is prevented by cycloheximide. A variant population of cells deficient in cyclic AMP-dependent protein kinase contains lower basal phosphodiesterase activity, which cannot be induced by cyclic AMP.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Phosphodiesterases and Cyclic Nucleotide Signaling in Endocrine Cells.
M. Conti (2000)
Mol. Endocrinol. 14, 1317-1327
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Cyclic AMP-dependent protein kinase: pivotal role in regulation of enzyme induction and growth.
P. Insel, H. Bourne, P Coffino, and G. Tomkins (1975)
Science 190, 896-898
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Selection of a variant lymphoma cell deficient in adenylate cyclase.
H. Bourne, P Coffino, and G. Tomkins (1975)
Science 187, 750-752
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