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Science 7 September 1973:
Vol. 181. no. 4103, pp. 947 - 949
DOI: 10.1126/science.181.4103.947
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Articles

Growth Retardation in Young Mice Treated with dl-Methadone

M. Crofford 1 and A. A. Smith 1

1 Departments of Anesthesiology and Pharmacology, New York Medical College, New York 10029

Newborn mice injected daily for 6 weeks with dl-methadone in dosages of 2 to 8 milligrams per kilogram grew significantly more slowly than their saline-treated littermates. Litters given d-methadone, 4 milligrams per kilogram, grew normally. Concomitant treatment with naloxone, 10 milligrams per kilogram, prevented growth inhibition. A weight deficit persisted in mice observed 6 weeks after cessation of methadone treatment.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)