Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 31 August 1973:
Vol. 181. no. 4102, pp. 872 - 873
DOI: 10.1126/science.181.4102.872
Prev | Table of Contents | Next

Articles

Genetic Control of Susceptibility to Experimental Allergic Encephalomyelitis in Rats

David L. Gasser 1, Carol M. Newlin 2, Joy Palm 3, and Nicholas K. Gonatas 4

1 Department of Human Genetics, University of Pennsylvania, Philadelphia 19174
2 Department of Biochemistry, University of Pennsylvania
3 Wistar Institute of Anatomy and Biology
4 Division of Neuropathology, Department of Pathology, University of Pennsylvania School of Medicine

Rats of the inbred strains Lewis and DA are highly susceptible to the induction of experimental allergic encephalomyelitis (EAE) while Brown Norway rats are resistant to this disease. Evidence has been obtained which suggests that a single dominant gene is associated with susceptibility to EAE. The locus controlling EAE susceptibility is closely linked to the Ag-B histocompatibility locus but is not identical to it.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Glyconanoparticles allow pre-symptomatic in vivo imaging of brain disease.
S. I. van Kasteren, S. J. Campbell, S. Serres, D. C. Anthony, N. R. Sibson, and B. G. Davis (2009)
PNAS 106, 18-23
   Abstract »    Full Text »    PDF »
Nitric Oxide Contributes to Resistance of the Brown Norway Rat to Experimental Autoimmune Encephalomyelitis.
M. A. Staykova, J. T. Paridaen, W. B. Cowden, and D. O. Willenborg (2005)
Am. J. Pathol. 166, 147-157
   Abstract »    Full Text »    PDF »
Studies of Congenic Lines in the Brown Norway Rat Model of Th2-Mediated Immunopathological Disorders Show That the Aurothiopropanol Sulfonate-Induced Immunological Disorder (Aiid3) Locus on Chromosome 9 Plays a Major Role Compared to Aiid2 on Chromosome 10.
M. Mas, P. Cavailles, C. Colacios, J.-F. Subra, D. Lagrange, M. Calise, M.-O. Christen, P. Druet, L. Pelletier, D. Gauguier, et al. (2004)
J. Immunol. 172, 6354-6361
   Abstract »    Full Text »    PDF »
Susceptibility and Resistance to Experimental Allergic Encephalomyelitis: Relationship with Hypothalamic-Pituitary-Adrenocortical Axis Responsiveness in the Rat.
A. Stefferl, C. Linington, F. Holsboer, and J. M. H. M. Reul (1999)
Endocrinology 140, 4932-4938
   Abstract »    Full Text »
Myelin Oligodendrocyte Glycoprotein Induces Experimental Autoimmune Encephalomyelitis in the ""Resistant"" Brown Norway Rat: Disease Susceptibility Is Determined by MHC and MHC-Linked Effects on the B Cell Response.
A. Stefferl, U. Brehm, M. Storch, D. Lambracht-Washington, C. Bourquin, K. Wonigeit, H. Lassmann, and C. Linington (1999)
J. Immunol. 163, 40-49
   Abstract »    Full Text »    PDF »
A Genome-Wide Search Identifies Two Susceptibility Loci for Experimental Autoimmune Encephalomyelitis on Rat Chromosomes 4 and 10.
M.-P. Roth, C. Viratelle, L. Dolbois, M. Delverdier, N. Borot, L. Pelletier, P. Druet, M. Clanet, and H. Coppin (1999)
J. Immunol. 162, 1917-1922
   Abstract »    Full Text »    PDF »
Histocompatibility Determinants in Childhood Postinfectious Encephalomyelitis.
R. C. Woody, R. W. Steele, R. K. Charlton, and V. Smith (1989)
J Child Neurol 4, 204-207
   Abstract »    PDF »
Spinal fluid differences in experimental allergic encephalomyelitis and multiple sclerosis.
H. Gutstein and Cohen SR (1978)
Science 199, 301-303
   Abstract »    PDF »
Sperm autoantibodies in vasectomized rats of different inbred strains.
P. Bigazzi, L. Kosuda, and L. Harnick (1977)
Science 197, 1282-1283
   Abstract »    PDF »
Histocompatibility Types and Viral Antibodies.
J. R. Lehrich and B. G. W. Arnason (1976)
Arch Neurol 33, 404-405
   Abstract »    PDF »
Inhibition of Experimental Allergic Encephalomyelitis in Rats Severely Depleted of T Cells.
N. K. Gonatas and J. C. Howard (1974)
Science 186, 839-841
   Abstract »    PDF »
Parainfluenza, Histocompatibility, and Multiple Sclerosis: Association of Parainfluenza Antibodies and Histocompatibility Types in MS and Optic Neuritis.
J. R. Lehrich, B. G. W. Arnason, T. C. Fuller, and S. H. Wray (1974)
Arch Neurol 30, 327-329
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)