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Science 31 August 1973:
Vol. 181. no. 4102, pp. 858 - 860
DOI: 10.1126/science.181.4102.858
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Articles

Infusion of 2-Deoxy-D-Glucose into the Hepatic-Portal System Causes Eating: Evidence for Peripheral Glucoreceptors

Donald Novin 1, Dennis A. VanderWeele 1, and Milan Rezek 1

1 Department of Psychology and Brain Research Institute, University of California, Los Angeles 90024

Injections of 2-deoxyglucose into the hepatic-portal system of normal rabbits increased eating to a greater extent and with shorter latency than comparable injections of 2-deoxyglucose into the jugular vein or into the hepaticportal circulation of the vagotomized rabbit. These differences suggest the existence of vagally mediated peripheral glucoreceptors important in the initiation of food intake.


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