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Science 31 August 1973:
Vol. 181. no. 4102, pp. 849 - 850
DOI: 10.1126/science.181.4102.849
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Articles

Peroxidase Mediated Antimicrobial Activities of Alveolar Macrophage Granules

B. B. Paul 1, R. R. Strauss 1, R. J. Selvaraj 1, and A. J. Sbarra 1

1 Department of Pathology and Medical Research, St. Margaret's Hospital, and Department of Obstetrics and Gynecology, Tufts University School of Medicine, Boston, Massachusetts 02125

The 20,000g pellet obtained by centrifugation of a homogenate of rabbit alveolar macrophages has antibacterial activity in the presence of a hydrogen peroxide-generating system and iodide. Peroxidase activity has been demonstrated in this fraction. Addition of 3-amino-1,2,4-triazole diminished the antibacterial activity of the pellet-hydrogen peroxide-iodide system.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Monocytes and Macrophages: Functions and Diseases.
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Singlet Oxygen: A Unique Microbicidal Agent in Cells.
T. H. Maugh II (1973)
Science 182, 44-45
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Protein Tyrosine Nitration in Cytokine-activated Murine Macrophages. INVOLVEMENT OF A PEROXIDASE/NITRITE PATHWAY RATHER THAN PEROXYNITRITE.
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Science. ISSN 0036-8075 (print), 1095-9203 (online)