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Science 31 August 1973:
Vol. 181. no. 4102, pp. 845 - 847
DOI: 10.1126/science.181.4102.845
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Articles

Human Chorionic Gonadotropin: Its Possible Role in Maternal Lymphocyte Suppression

Eugene W. Adcock III 1, François Teasdale 1, Charles S. August 1, Sheila Cox 1, Giacomo Meschia 1, Frederick C. Battaglia 1, and Michael A. Naughton 1

1 Division, of Perinatal Medicine, Departments of Pediatrics, Physiology, and Obstetrics-Gynecology, University of Colorado Medical Center, Denver 80220

Human chorionic gonadotropin completely inhibits the response of lymphocytes to phytohemagglutinin. The effect is both reversible and noncytotoxic. These observations support the theory that the fetus is accepted because human chorionic gonadotropin represents trophoblastic surface antigen and blocks the action of maternal lymphocytes.


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