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Science 24 August 1973:
Vol. 181. no. 4101, pp. 762 - 764
DOI: 10.1126/science.181.4101.762
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Articles

MHPG Excretion in Depressive Disorders: Relation to Clinical Subtypes and Desynchronized Sleep

Joseph J. Schildkraut 1, Barbara A. Keeler 1, Mechtild Papousek 2, and Ernest Hartmann 2

1 Neuropsychopharmacology Laboratory, Massachusetts Mental Health Center, Boston 02115, and Department of Psychiatry, Harvard Medical School, Boston
2 Sleep and Dream Laboratory, Boston State Hospital, Boston 02124, and Department of Psychiatry, Tufts University School of Medicine, Boston 02111

The urinary excretion of 3-methoxy-4-hydroxyphenylglycol (MHPG) was significantly lower in patients with manic-depressive depressions than in patients with chronic characterological depressions. There was an inverse relationship between MHPG excretion and the amount of time spent in desynchronized sleep, particularly in the manic-depressive disorders. Excretion of MHPG was not related to the degree of retardation, agitation, or anxiety in these patients.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
State Anxiety, Physical Activity, and Urinary 3-Methoxy-4-Hydroxyphenethylene Glycol Excretion.
D. R. Sweeney, J. W. Maas, and G. R. Heninger (1978)
Arch Gen Psychiatry 35, 1418-1423
   Abstract »    PDF »
Toward a Biochemical Classification of Depressive Disorders: I. Differences in Urinary Excretion of MHPG and Other Catecholamine Metabolites in Clinically Defined Subtypes of Depressions.
J. J. Schildkraut, P. J. Orsulak, A. F. Schatzberg, J. E. Gudeman, J. O. Cole, W. A. Rohde, and R. A. LaBrie (1978)
Arch Gen Psychiatry 35, 1427-1433
   Abstract »    PDF »
Primary Affective Disorder, Clinical State Change, and MHPG Excretion: A Longitudinal Study.
D. Pickar, D. R. Sweeney, J. W. Maas, and G. R. Heninger (1978)
Arch Gen Psychiatry 35, 1378-1383
   Abstract »    PDF »
Catecholamine Metabolism in Anorexia Nervosa.
K. A. Halmi, H. Dekirmenjian, J. M. Davis, R. Casper, and S. Goldberg (1978)
Arch Gen Psychiatry 35, 458-460
   Abstract »    PDF »
Clinical and Biochemical Heterogeneity of Depressive Disorders.
J. W. MAAS (1978)
Ann Intern Med 88, 556-563
   Abstract »    PDF »
The Switch Process in Manic-Depressive Psychosis.
W. E. BUNNEY Jr., T. R. WEHR, J. C. GILLIN, R. M. POST, F. K. GOODWIN, and D. P. van KAMMEN (1977)
Ann Intern Med 87, 319-335
   Abstract »    PDF »
CNS Monoamine Metabolism in Bipolar Affective Disorder: Evaluation Using a Peripheral Decarboxylase Inhibitor.
P. E. Garfinkel, J. J. Warsh, H. C. Stancer, and D. D. Godse (1977)
Arch Gen Psychiatry 34, 735-739
   Abstract »    PDF »
Biogenic Amines and Depression: Biochemical and Pharmacological Separation of Two Types of Depression.
J. W. Maas and J. W. Maas (1975)
Arch Gen Psychiatry 32, 1357-1361
   Abstract »    PDF »
Norepinephrine Uptake into Cerebral Cortical Synaptosomes after One Fight or Electroconvulsive Shock.
B. L. Welch, E. D. Hendley, and I. Turek (1974)
Science 183, 220-221
   Abstract »    PDF »


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