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Science 24 August 1973:
Vol. 181. no. 4101, pp. 755 - 757
DOI: 10.1126/science.181.4101.755
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Articles

Osmolar Control of Prolactin Secretion in Man

Maire T. Buckman 1 and Glenn T. Peake 1

1 Department of Medicine, University of New Mexico School of Medicine, and Lovelace-Bataan Medical Center, Albuquerque, New Mexico 87106

To study the effect of changing serum osmolality on serum prolactin concentration 11 volunteers were given oral and intravenous hypotonic and hypertonic fluids. Mean serum prolactin fell to 10.5 percent of baseline after oral water loading and to 15 percent of baseline after intravenous hypotonic saline infusion. Conversely, mean prolactin rose to 417 percent of baseline after intravenous hypertonic saline administration. The correlation coefficient of simultaneously determined serum prolactin and osmolality was highly significant (P lang .001). Isoosmolar changes in extracellular fluid volume did not consistently affect the concentration of prolactin in the serum. Thus, prolactin may be involved in the physiologic regulation of osmolar balance and the kidney may be an important farget organ for prolaction.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Lactate Provocation of Panic Attacks: II. Biochemical and Physiological Findings.
M. R. Liebowitz, J. M. Gorman, A. J. Fyer, M. Levitt, D. Dillon, G. Levy, I. L. Appleby, S. Anderson, M. Palij, S. O. Davies, et al. (1985)
Arch Gen Psychiatry 42, 709-719
   Abstract »    PDF »
Prolactin in Clinical Practice.
M. T. Buckman and G. T. Peake (1976)
JAMA 236, 871-874
   Abstract »    PDF »
Serum Prolactin Levels in Unmedicated Schizophrenic Patients.
H. Y. Meltzer, E. J. Sachar, and A. G. Frantz (1974)
Arch Gen Psychiatry 31, 564-569
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