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Science 17 August 1973:
Vol. 181. no. 4100, pp. 674 - 676
DOI: 10.1126/science.181.4100.674
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Articles

Human Papovavirus (JC): Induction of Brain Tumors in Hamsters

Duard L. Walker 1, Billie L. Padgett 1, Gabriele M. ZuRhein 1, Albertina E. Albert 1, and Richard F. Marsh 2

1 Departments of Medical Microbiology and Pathology, University of Wisconsin Medical School, Madison 53706
2 Department of Veterinary Science, University of Wisconsin Agricultural and Life Sciences, Madison 53706

Eighty-three percent of hamsters inoculated at birth with JC virus, a human papovavirus isolated from brain tissue of a case of progressive multifocal leukoencephalopathy, developed malignant gliomas within 6 months. Three brain tumors have been serially transplanted as subcutaneous tumors. JC virus was isolated from five of seven tumors tested. Cells from four tumors were cultivated in vitro. These cells contained an intranuclear antigen with the characteristics of a T antigen, and this antigen was antigenically related to SV40 T antigen. Although virus was not recovered from extracts of serially cultured tumor cells, JC virus was rescued when one tumor cell line was fused with permissive cells.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Rearrangement of Simian Virus 40 Regulatory Region Is Not Required for Induction of Progressive Multifocal Leukoencephalopathy in Immunosuppressed Rhesus Monkeys.
X. Dang, M. K. Axthelm, N. L. Letvin, and I. J. Koralnik (2005)
J. Virol. 79, 1361-1366
   Abstract »    Full Text »    PDF »
Simian Virus 40 Infection of Humans.
R. L. Garcea and M. J. Imperiale (2003)
J. Virol. 77, 5039-5045
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Members of the AP-1 Family, c-Jun and c-Fos, Functionally Interact with JC Virus Early Regulatory Protein Large T Antigen.
J. Kim, S. Woolridge, R. Biffi, E. Borghi, A. Lassak, P. Ferrante, S. Amini, K. Khalili, and M. Safak (2003)
J. Virol. 77, 5241-5252
   Abstract »    Full Text »    PDF »
Detection of JC Polyomavirus DNA Sequences and Cellular Localization of T-Antigen and Agnoprotein in Oligodendrogliomas.
L. Del Valle, S. Enam, C. Lara, C. Ortiz-Hidalgo, C. D. Katsetos, and K. Khalili (2002)
Clin. Cancer Res. 8, 3332-3340
   Abstract »    Full Text »    PDF »
Expression of Human Neurotropic Polyomavirus JCV Late Gene Product Agnoprotein in Human Medulloblastoma.
L. Del Valle, J. Gordon, S. Enam, S. Delbue, S. Croul, S. Abraham, S. Radhakrishnan, M. Assimakopoulou, C. D. Katsetos, and K. Khalili (2002)
J Natl Cancer Inst 94, 267-273
   Abstract »    Full Text »    PDF »
Expression of a human polyomavirus oncoprotein and tumour suppressor proteins in medulloblastomas.
L Del Valle, J Baehring, C Lorenzana, A Giordano, K Khalili, and S Croul (2001)
Mol. Pathol. 54, 331-337
   Abstract »    Full Text »    PDF »
Detection of JC Virus DNA Sequences and Expression of the Viral Regulatory Protein T-Antigen in Tumors of the Central Nervous System.
L. D. Valle, J. Gordon, M. Assimakopoulou, S. Enam, J. F. Geddes, J. N. Varakis, C. D. Katsetos, S. Croul, and K. Khalili (2001)
Cancer Res. 61, 4287-4293
   Abstract »    Full Text »
Analysis of Capsid Formation of Human Polyomavirus JC (Tokyo-1 Strain) by a Eukaryotic Expression System: Splicing of Late RNAs, Translation and Nuclear Transport of Major Capsid Protein VP1, and Capsid Assembly.
Y. Shishido-Hara, Y. Hara, T. Larson, K. Yasui, K. Nagashima, and G. L. Stoner (2000)
J. Virol. 74, 1840-1853
   Abstract »    Full Text »
Physical and Functional Interaction between the Y-Box Binding Protein YB-1 and Human Polyomavirus JC Virus Large T Antigen.
M. Safak, G. L. Gallia, S. A. Ansari, and K. Khalili (1999)
J. Virol. 73, 10146-10157
   Abstract »    Full Text »
JC virus DNA is present in the mucosa of the human colon and in colorectal cancers.
L. Laghi, A. E. Randolph, D. P. Chauhan, G. Marra, E. O. Major, J. V. Neel, and C. R. Boland (1999)
PNAS 96, 7484-7489
   Abstract »    Full Text »    PDF »
Interaction of the Single-stranded DNA-binding Protein Puralpha with the Human Polyomavirus JC Virus Early Protein T-antigen.
G. L. Gallia, M. Safak, and K. Khalili (1998)
J. Biol. Chem. 273, 32662-32669
   Abstract »    Full Text »    PDF »
Human Polyomavirus Infections with JC Virus and BK Virus in Renal Transplant Patients.
T. F. HOGAN, E. C. BORDEN, J. A. McBAIN, B. L. PADGETT, and D. L. WALKER (1980)
Ann Intern Med 92, 373-378
   Abstract »    PDF »
Brain tumors in owl monkeys inoculated with a human polyomavirus (JC virus).
W. London, S. Houff, D. Madden, D. Fuccillo, M Gravell, W. Wallen, A. Palmer, J. Sever, B. Padgett, D. Walker, et al. (1978)
Science 201, 1246-1249
   Abstract »    PDF »
Progressive Multifocal Leukoencephalopathy in Renal Transplant Recipients.
W. F. McCormick, S. S. Schochet Jr, H. E. Sarles, and J. R. Calverley (1976)
Arch Intern Med 136, 829-834
   Abstract »    PDF »
Human Adenovirus Infection in Monkey Cells: An Example of Host Restriction at a Step Late in Replication.
S. G. Baum and R. I. Fox (1974)
Cold Spring Harb Symp Quant Biol 39, 567-573
   Abstract »    PDF »
Koch's Postulates and Slow Infections of the Nervous System.
R. T. Johnson and C. J. Gibbs Jr. (1974)
Arch Neurol 30, 36-38
   Abstract »    PDF »


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