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Science 10 August 1973:
Vol. 181. no. 4099, pp. 561 - 562
DOI: 10.1126/science.181.4099.561
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Articles

Exocytosis-Endocytosis Coupling in the Pancreatic Beta Cell

L. Orci 1, F. Malaisse-Lagae 1, M. Ravazzola 1, M. Amherdt 1, and A. E. Renold 2

1 Institute of Histology, University of Geneva, Geneva, Switzerland
2 Institute of Clinical Biochemistry, University of Geneva

The stimulation of the release of insulin by glucose is accompanied by an enhanced uptake of cytochemically demonstrable horseradish peroxidase into endocytotic vesicles within the beta cells. An exocytosis-endocytosis coupling might represent a mechanism by which membrane constituents are recycled within the beta cells under conditions of increased secretory activity.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Ins and Outs of Secretion from Pancreatic {beta}-Cells: Control of Single-Vesicle Exo- and Endocytosis.
P. E. MacDonald and P. Rorsman (2007)
Physiology 22, 113-121
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Calcium increases endocytotic vesicle size and accelerates membrane fission in insulin-secreting INS-1 cells.
P. E. MacDonald, L. Eliasson, and P. Rorsman (2005)
J. Cell Sci. 118, 5911-5920
   Abstract »    Full Text »    PDF »
Sequential compound exocytosis of large dense-core vesicles in PC12 cells studied with TEPIQ (two-photon extracellular polar-tracer imaging-based quantification) analysis.
T. Kishimoto, T.-T. Liu, H. Hatakeyama, T. Nemoto, N. Takahashi, and H. Kasai (2005)
J. Physiol. 568, 905-915
   Abstract »    Full Text »    PDF »
Calcium and secretion: distinction between two pools of glucose-sensitive calcium in pancreatic islets.
B Hellman, J Sehlin, and I. Taljedal (1976)
Science 194, 1421-1423
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)