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Science 3 August 1973:
Vol. 181. no. 4098, pp. 458 - 459
DOI: 10.1126/science.181.4098.458
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Articles

Infertility in Female Rabbits Immunized with Lactate Dehydrogenase X

Erwin Goldberg 1

1 Department of Biological Sciences, Northwestern University, Evanston, Illinois 60201

Immunization of female rabbits with the sperm-specific lactate dehydrogenase (LDH-X) resulted in a highly significant reduction of pregnancies compared to nonimmunized controls. This is the first demonstration of immunosuppression of fertility by a crystalline protein shown to be strictly homogeneous by ultracentrifugation, polyacrylamide gel electrophoresis, immunodiffusion, and micro complement fixation.


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