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Science 3 August 1973:
Vol. 181. no. 4098, pp. 445 - 446
DOI: 10.1126/science.181.4098.445
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Articles

Glucose Naturally Labeled with Carbon-13: Use for Metabolic Studies in Man

Marcel Lacroix 1, Florentina Mosora 1, Micheline Pontus 1, Pierre Lefebvre 2, Alfred Luyckx 2, and Gabriel Lopez-Habib 2

1 Department of Atomic and Molecular Physics, University of Liège, B-4000 Liège, Belgium
2 Divsion of Diabetes, Institute of Medicine, University of Liège

The ratio of carbon-13 to carbon-12 is much higher in most commerical preparations of glucose used for oral glucose tolerance tests than it is in carbon dioxide in expired air. This recent discovery provided a novel and potentially significant means of studying glucose metabolism. The changes in the ratio of carbon-13 to carbon-12 in carbon dioxide expired after oral glucose administration were determined by mass spectrometry. In six healthy male volunteers, the administration of glucose resulted in a marked, reproducible rise in the isotopic ratio in expired carbon dioxide; the ratio reached its maximum at 4 hours and then declined progressively.


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