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Science 27 July 1973:
Vol. 181. no. 4097, pp. 347 - 350
DOI: 10.1126/science.181.4097.347
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Articles

Vasopressin: Possible Role of Microtubules and Microfilaments in Its Action

Ann Taylor 1, Mortimer Mamelak 1, Eve Reaven 1, and Roy Maffly 1

1 Department of Medicine, Stanford University School of Medicine, and Veterans Administration Hospital, Palo Alto, California 94304

Colchicine, vinblastine, podophyllotoxin, and cytochalasin B inhibit the action of vasopressin and cyclic adenosine monophosphate on osmotic water movement across the toad bladder. The findings suggest that microtubules, and possibly microfilaments, play a role in the action of vasopressin, perhaps through involvement in the mechanism of release of secretory material from the bladder epithelial cells.


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