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Science 6 July 1973:
Vol. 181. no. 4094, pp. 76 - 78
DOI: 10.1126/science.181.4094.76
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Articles

Regulation of Muscle Acetylcholine Sensitivity by Muscle Activity in Cell Culture

Stephen A. Cohen 1 and Gerald D. Fischbach 1

1 Behavioral Biology Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20014

Muscle in tissue culture provides a good system for studying longterm changes in surface membrane acetylcholine sensitivity. Muscle fibers stimulated intermittently over prolonged periods are less sensitive to iontophoretically applied acetylcholine and bind less 125I-labeled agr-bungarotoxin than inactive fibers.


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