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Science 6 July 1973:
Vol. 181. no. 4094, pp. 71 - 73
DOI: 10.1126/science.181.4094.71
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Articles

Nonhistone Chromosomal Protein Synthesis: Utilization of Preexisting and Newly Transcribed Messenger RNA's

Gary S. Stein 1 and David E. Matthews 1

1 Department of Biochemistry, University of Florida, Gainesville 32601

Treatment of HeLa S3 cells with actinomycin D during mitosis suppresses the synthesis of several major classes of nonhistone chromosomal proteins during the subsequent period before DNA replication, but allows the synthesis of other species of these proteins. Such results are consistent with the utilization of preexisting, as well as newly transcribed, messenger RNA's for nonhistone chromosomal protein synthesis during the prereplicative phase of the cell cycle.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Nonhistone Chromosomal Proteins and Gene Regulation: Nonhistone chromosomal proteins may participate in the specific regulation of gene transcription in eukaryotes.
G. S. Stein, T. C. Spelsberg, and L. J. Kleinsmith (1974)
Science 183, 817-824
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