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Science 29 June 1973:
Vol. 180. no. 4093, pp. 1364 - 1366
DOI: 10.1126/science.180.4093.1364
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Articles

Postlesion Axonal Growth Produces Permanent Functional Connections

Gary Lynch 1, Sam Deadwyler 1, and Carl Cotman 1

1 Department of Psychobiology, University of California, Irvine 92664

Lesions of the entorhinal cortex in neonatal rats cause the commissural projections to the dentate gyrus to spread from their normal location in the inner molecular layer into the outer molecular layer, a region normally occupied by afferents from the entorhinal cortex. These lesions also cause the short-latency response to commissural stimulation to spread into the outer molecular layer, a result suggesting that these abnormally located connections are operative.


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