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Science 22 June 1973:
Vol. 180. no. 4092, pp. 1295 - 1297
DOI: 10.1126/science.180.4092.1295
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Articles

Axonal Transport of Dopamine-beta-Hydroxylase by Human Sural Nerves in vitro

Stephen Brimijoin 1, Patrick Capek 1, and Peter James Dyck 1

1 Departments of Pharmacology and Neurology, Mayo Clinic, Rochester, Minnesota 55901

Dopamine-beta-hydroxylase activity accumulated above a ligature on biopsy samples of normal human sural nerves incubated in vitro. The rate of accumulation indicated that this enzyme was transported distally at a velocity of 2 millimeters per hour. Axoplasmic transport of dopamine-beta-hydroxylase was greatly reduced in sural nerves from a few patients with peripheral neuropathies.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Dejerine-Sottas Disease Revisited.
R. Satran (1980)
Arch Neurol 37, 67-68
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Science. ISSN 0036-8075 (print), 1095-9203 (online)