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Science 15 June 1973:
Vol. 180. no. 4091, pp. 1190 - 1192
DOI: 10.1126/science.180.4091.1190
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Articles

Antibodies to a Precursor of Human Collagen

Charles J. Sherr 1 and Burton Goldberg 1

1 Department of Pathology, New York University Medical Center, New York 10016

Antiserum prepared against serum-free medium from human fibroblast cultures reacted specifically with protropocollagen, an assembled, soluble precursor of tropocollagen. The antibodies were directed to antigenic determinants in the nonhelical, amino terminal peptide extensions (propeptides). Amino acid sequences in the precursor molecule corresponding to the telopeptides and helical alpha chains of tropocollagen were not recognized by the antiserum.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Radioimmunoassay for Human Procollagen.
M. B. Taubman, B. Goldberg, and C. J. Sherr (1974)
Science 186, 1115-1117
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Science. ISSN 0036-8075 (print), 1095-9203 (online)