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Science 15 June 1973:
Vol. 180. no. 4091, pp. 1181 - 1183
DOI: 10.1126/science.180.4091.1181
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Articles

Enzyme Release from Polymorphonuclear Leukocyte Lysosomes: Regulation by Autonomic Drugs and Cyclic Nucleotides

Louis J. Ignarro 1 and Carmelo Colombo 1

1 Research Department, Pharmaceutical Division, CIBA-GEIGY Corporation, Ardsley, New York 10502

Osmotic release of beta-glucuronidase from polymorphonuclear leukocyte lysosomes is inhibited by catecholamines and adenosine 3',5'-monophosphate, and accelerated by cholinergic agents and guanosine 3',5'-monophosphate. These actions are specific for the sympathetic and parasympathetic neurotransmitters and for the two cyclic nucleotides, as phenylephrine, tyramine, choline, adenosine 5'-monophosphate and guanosine 5'-monophosphate do not inodify lysosomal enzyme release.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Histamine inhibition of neutrophil lysosomal enzyme release: an H2 histamine receptor response.
W. Busse and J Sosman (1976)
Science 194, 737-738
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Hormonal Control of Neutrophil Lysosomal Enzyme Release: Effect of Epinephrine on Adenosine 3',5'-Monophosphate.
L. J. Ignarro, R. J. Paddock, and W. J. George (1974)
Science 183, 855-857
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