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Science 8 June 1973:
Vol. 180. no. 4090, pp. 1071 - 1072
DOI: 10.1126/science.180.4090.1071
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Articles

Estimation of the Half-Life of a Secretory Protein Message

S. Grayson 1 and S. J. Berry 1

1 Department of Biology, Wesleyan University, Middletown, Connecticut 06457

Synthesis of a specific secretory protein was followed in the presence of actinomycin D and cordycepin (3'-deoxyadenosine). The apparent half-life of the messenger RNA for this protein is significantly longer in the presence of actinomycin D than in the presence of cordycepin. These results suggest that actinomycin D studies of half-life in specialized cells may be inaccurate.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Stochastic and Nonstochastic Post-Transcriptional Silencing of Chitinase and ß-1,3-Glucanase Genes Involves Increased RNA Turnover—Possible Role for Ribosome-Independent RNA Degradation.
H. Holtorf, H. Schob, C. Kunz, R. Waldvogel, and F. Meins , Jr. (1999)
PLANT CELL 11, 471-484
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Science. ISSN 0036-8075 (print), 1095-9203 (online)