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Science 8 June 1973:
Vol. 180. no. 4090, pp. 1069 - 1071
DOI: 10.1126/science.180.4090.1069
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Articles

Virus-Induced Transformation without Cell Division

John P. Bader 1

1 Chemistry Branch, National Cancer Institute, Bethesda, Maryland 20014

Interference with the cell cycle by vinblastine sulfate immediately after cells were infected with Rous sarcoma virus had little effect on the a development of two metabolic changes that occur in transformed cells. These results, along with an earlier demonstration of morphological changes developing in infected nondividing cells, demonstrate that the phenotypic development of the malignant state can occur without the intervention of cell divisions after infection by Rous sarcoma virus.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)