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Science 8 June 1973:
Vol. 180. no. 4090, pp. 1067 - 1069
DOI: 10.1126/science.180.4090.1067
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Articles

Genetic Polymorphism of Proline-Rich Human Salivary Proteins

Edwin A. Azen 1 and Frank G. Oppenheim 2

1 Department of Medicine, University of Wisconsin, Madison 53706
2 Departments of Biochemistry and Oral Biology, Boston University School of Medicine and School of Graduate Dentistry, Boston, Massachusetts 02118

In randomly collected saliva samples from 120 Caucasians, 79 Blacks, and 40 Chinese, three phenotypes were observed by electrophoresis in alkaline slab polyacrylamide gels. The proteins showing polymorphism were identical with four previously characterized proline-rich proteins. Inheritance is controlled by two autosomal codominant alleles. The gene frequencies were for Caucasians, Prl=0.73, Pr2=0.27; for Blacks, Pr1=0.80, Pr2=0.20; for Chinese, Prl=0.84, Pr2=0.16.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Identification of Protein Components in Human Acquired Enamel Pellicle and Whole Saliva Using Novel Proteomics Approaches.
Y. Yao, E. A. Berg, C. E. Costello, R. F. Troxler, and F. G. Oppenheim (2003)
J. Biol. Chem. 278, 5300-5308
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Intracellular Transport and Secretion of Salivary Proteins.
D. Castle and A. Castle (1998)
Critical Reviews in Oral Biology & Medicine 9, 4-22
   Abstract »    Full Text »    PDF »
Human Salivary Acidic Proline-rich Protein Polymorphisms and Biosynthesis Studied by High-performance Liquid Chromatography.
D.I. Hay, J.M. Ahern, S.K. Schluckebier, and D.H. Schlesinger (1994)
Journal of Dental Research 73, 1717-1726
   Abstract »    PDF »
Genetics of Salivary Protein Polymorphisms.
E. A. Azen (1993)
Critical Reviews in Oral Biology & Medicine 4, 479-485
   Abstract »    Full Text »    PDF »
A Contemporary View of Salivary Research.
I. D. Mandel (1993)
Critical Reviews in Oral Biology & Medicine 4, 599-604
   Abstract »    Full Text »    PDF »
Polymorphism of Submandibular-Sublingual Salivary Proteins which Promote Adhesion of Streptococcus mutans Serotype-c Strains to Hydroxyapatite.
E. Kishimoto, D.I. Hay, and R. Kent (1990)
Journal of Dental Research 69, 1741-1745
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Invited Review: Genetics of Human Salivary Proteins.
K. Minaguchi and A. Bennick (1989)
Journal of Dental Research 68, 2-15
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Structural and Genetic Aspects of Proline-rich Proteins.
A. Bennick (1987)
Journal of Dental Research 66, 457-461
   Abstract »    PDF »
New Genetic marker in human parotid saliva (pm).
S Ikemoto, K Minaguchi, K Suzuki, and K Tomita (1977)
Science 197, 378-379
   Abstract »    PDF »
Relation of Saliva and Plaque to Caries.
I. D. Mandel (1974)
Journal of Dental Research 53, 246-266
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Science. ISSN 0036-8075 (print), 1095-9203 (online)