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Science 1 June 1973:
Vol. 180. no. 4089, pp. 966 - 968
DOI: 10.1126/science.180.4089.966
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Articles

Transfer of Experimental Autoimmune Renal Cortical Tubular and Interstitial Disease in Guinea Pigs by Serum

Raymond W. Steblay 1 and Ulrich Rudofsky 1

1 New York State Kidney Disease Institute and Department of Pathology, Albany Medical College, Albany, New York 12208

Guinea pigs injected with rabbit tubular basement membranes and Freund's adjuvant develop progressive renal cortical tubulointerstitial disease and deposit autoantibodies in their cortical tubular basement membranes. The identical, even fatal, disease may be produced in normal guinea pigs by a single intraperitoneal injection of serums obtained from guinea pigs with this tubulointerstitial disease, provided such serums contain sufficient amounts of autoantibodies against tubular basement membranes.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
IgA Antibasement Membrane Nephritis with Pulmonary Hemorrhage.
W. A. BORDER, R. W. BAEHLER, D. BHATHENA, and R. J. GLASSOCK (1979)
Ann Intern Med 91, 21-25
   Abstract »    PDF »
Complement-dependent immunoglobulin G receptor function in lymphoid cells.
J. Scornik (1976)
Science 192, 563-565
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)