Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 1 June 1973:
Vol. 180. no. 4089, pp. 964 - 966
DOI: 10.1126/science.180.4089.964
Prev | Table of Contents | Next

Articles

Isotachysterol3 and 25-Hydroxyisotachysterol3: Analogs of 1,25-Dihydroxyvitamin D3

M. F. Holick 1, H. F. DeLuca 1, P. M. Kasten 1, and M. B. Korycka 1

1 Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin-Madison, Madison 53706

Isotachysterol3, 25-hydroxyisotachysterol3, and isovitamin D3 have been synthesized and tested for biological activity. Like 1,25-dihydroxyvitamin D3, isotachysterol3 stimulates intestinal calcium transport and bone calcium mobilization in anephric rats, whereas 25-hydroxyvitamin D3 does not. Although isovitamin D3 is biologically active in normal rats it is inactive in anephric rats.

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)