Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 25 May 1973:
Vol. 180. no. 4088, p. 875
DOI: 10.1126/science.180.4088.875
Prev | Table of Contents | Next

Articles

Osteopetrosis Cured by Temporary Parabiosis

Donald G. Walker 1

1 Department of Anatomy, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205

The excessive accumulations of spongiosa in the long bones of congenitally osteopetrotic mice permanently disappeared after a brief parabiotic union to normal littermates. Most of the bone removal was accomplished long after interruption of parabiosis. It is proposed that, during parabiosis, progenitors of competent osteolytic cells were recruited from the blood of the normal mouse.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Osteoblasts May Take a Road Well-Traveled.
F. H. Chen, C. JX. Lee, and J. E. Aubin (2005)
IBMS BoneKEy 2, 14-18
   Full Text »    PDF »
Osteopetrosis.
J. Tolar, S. L. Teitelbaum, and P. J. Orchard (2004)
N. Engl. J. Med. 351, 2839-2849
   Full Text »    PDF »
Deficiency of SHP-1 Protein-Tyrosine Phosphatase Activity Results in Heightened Osteoclast Function and Decreased Bone Density.
S. Umeda, W. G. Beamer, K. Takagi, M. Naito, S.-I. Hayashi, H. Yonemitsu, T. Yi, and L. D. Shultz (1999)
Am. J. Pathol. 155, 223-233
   Abstract »    Full Text »    PDF »
Current Concepts Review - Cellular Biology of Bone-Resorbing Cells.
N. A. ATHANASOU (1996)
J. Bone Joint Surg. Am. 78, 1096-1112
   Full Text »
Osteoclast Differentiation.
G. D. Roodman (1991)
Critical Reviews in Oral Biology & Medicine 2, 389-409
   Abstract »    Full Text »    PDF »
Osteopetrosis of the Temporal Bone.
M. Hawke, A. F. Jahn, and D. Bailey (1981)
Arch Otolaryngol Head Neck Surg 107, 278-282
   Abstract »    PDF »
Contact-mediated bone resorption by human monocytes in vitro.
A. Kahn, C. Stewart, and S. Teitelbaum (1978)
Science 199, 988-990
   Abstract »    PDF »
Bone resorption restored in osteopetrotic mice by transplants of normal bone marrow and spleen cells.
D. Walker (1975)
Science 190, 784-785
   Abstract »    PDF »
Spleen cells transmit osteopetrosis in mice.
D. Walker (1975)
Science 190, 785-787
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)