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Science 25 May 1973:
Vol. 180. no. 4088, pp. 868 - 870
DOI: 10.1126/science.180.4088.868
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Articles

Macrophage Nonimmunologic Recognition: Target Cell Factors Related to Contact Inhibition

John B. Hibbs Jr. 1

1 Veterans Administration Hospital and Department of Medicine, Division of Infectious Diseases, University of Utah Medical Center, Salt Lake City 84112

Activated mouse macrophages were not cytotoxic to contact-inhibited nontumorigenic 3T3 fibroblasts, but caused marked destruction to non-contact-inhibited, tumorigenic 3T12 and simian virus 40-transformed fibroblasts. Nonimmunologic recognition and destruction of target cells by activated macrophages is independent of altered morphology, abnormal karyotype, and ability for continuous multiplication in vitro—all characteristics of 3T3 fibroblasts. A modification e f the target cell surface that results in a high in vitro saturation density, agglutinability by plant lectins, and tumorigenicity appears to evoke a cytotoxic response by activated macrophages.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Tumor surveillance: how tumors may resist macrophage-mediated host defense.
J Rhodes, M Bishop, and J Benfield (1979)
Science 203, 179-182
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Macrophage tumor killing: influence of the local environment.
J. Hibbs Jr, R. Taintor, H. Chapman Jr, and J. Weinberg (1977)
Science 197, 279-282
   Abstract »    PDF »
Heterocytolysis by Macrophages Activated by Bacillus Calmette-Guerin: Lysosome Exocytosis into Tumor Cells.
J. B. Hibbs Jr. (1974)
Science 184, 468-471
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)