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Science 25 May 1973:
Vol. 180. no. 4088, pp. 865 - 866
DOI: 10.1126/science.180.4088.865
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Articles

Segregation of Loci for C-Type Virus Induction in Strains of Mice with High and Low Incidence of Leukemia

John R. Stephenson 1 and Stuart A. Aaronson 1

1 Viral Carcinogenesis Branch, National Cancer Institute, Bethesda, Maryland 20014

Multiple genetic loci for induction of murine leukemia viruses are demonstrated in cells of the high leukemic incidence C58 mouse strain. The biologic properties of viruses at C58 inducibility loci are clearly distinguishable from those of viruses activated from mouse cells containing a locus for virus induction of the low leukemia incidence BALB/c strain. These findings are consistent with the hypothesis that the genes for virus induction in normal mouse embryo cells represent viral structural information.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
High-Frequency C-Type Virus Induction by Inhibitors of Protein Synthesis.
S. A. Aaronson and C. Y. Dunn (1974)
Science 183, 422-424
   Abstract »    PDF »
Qualitative and Quantitative Studies of AKR-type Murine Leukemia Virus Sequences in Mouse DNA.
S. K. Chattopadhyay, D. R. Lowy, N. M. Teich, A. S. Levine, and W. P. Rowe (1974)
Cold Spring Harb Symp Quant Biol 39, 1085-1101
   Abstract »    PDF »
Differential Cellular Regulation of Three Distinct Classes of Type C RNA Viruses Endogenous to Mouse Cells.
S. A. Aaronson and J. R. Stephenson (1974)
Cold Spring Harb Symp Quant Biol 39, 1129-1137
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)